Ac-(D)-Asp-MA-Nle-Nle-Leu-Pro-Trp-Pro-OH, "ZED1301"

- Overview
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    Background
    
    Peptidic inhibitor containing an electrophilic Michael acceptor (MA) warhead
    
    More Details
    
    Zedira
- Properties
  - Name
    
    ZED1301
    
    Purification
    
    >95 % (214 nm)
    
    Note
    
    INTENDED FOR RESEARCH USE ONLY, NOT FOR USE IN HUMAN, THERAPEUTIC OR DIAGNOSTIC APPLICATIONS.
    
    Molecular Weight
    
    1064.23
    
    Class
    
    FXIII-Inhibitors
- Applications
  - Application Description
    
    Site specific irreversible inhibitor of plasma transglutaminase (factor XIII, FXIII)ZED1301 shows 30-fold selectivity for FXIII compared to tissue transglutaminaseIC50 = 100 nM (FXIII, using fluorescent Assay Substance A101[1])IC50 = 3000 nM (TG2, using fluorescent Assay Substance A101[1])
    [1] Oertel et al. Anal. Biochem. 2007, 367, 152.
- Reference
  - Stieler, M. et al. Angewandte Chemie Intl. Ed. 2013, 52, 11930.