A2A GPCR Adenosine Receptors Class A

- Overview
  - CALIXAR’s A2A GPCR (Adenosine receptor A2A) aids in the discovery, development, and validation of new molecules as well as therapeutic antibodies. They are ideal for CNS neuroprotection in order to develop new treatments for insomnia, pain, depression, Alzheimer and Parkinson’s diseases.
    
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    Background
    
    This class A GPCR is involved in the regulation of myocardial blood flow/hypertension. This protein has a N-terminal Step tag II and an 8X His tag followed by a TEV protease cleavage site.
    
    More Details
    
    CALIXAR
    
    Purified Membrane Proteins
- Properties
  - Source
    
    Human
    
    Purification
    
    Immobilized Metal Affinity Chromatography (Pruity: >90%)
    
    Formulation
    
    50mM Hepes pH 7.4, 200mM NaCl, 0.05%/0.006% DDM/CHS as sample buffer
    
    Storage
    
    Store at -80°C
    
    Concentration
    
    Up to 5mg/ml
    
    Molecular Weight
    
    47,7kDa
    
    Class
    
    Membrane Proteins
    
    Expression system
    
    Sf9 insect cells (baculovirus)
    
    Sequence
    
    Full-length, wildtype sequence, with a N-terminus Strep tag II, 8xHis-tag, and TEV protease cleavage site.
    
    Activity
    
    Confirmed by radiobinding assay
    
    More Information
    
    UniProt
    
    P29274
    
    * For Research Use Only
- Applications
  - Application Description
    
    CALIXAR’s A2A GPCR (Adenosine receptor A2A) aids in the discovery, development, and validation of new molecules as well as therapeutic antibodies.
- Reference
  - Enabling STD-NMR fragment screening using stabilized native GPCR : A case study of adenosine receptor. Igonet S et al. 2018
    Towards Native and Stable GPCRs for Conformational Antibody Development. Jawhari A. Boston, 2015
    Novel systematic detergent screening method for membrane proteins solubilization. Desuzinges Mandon E. et al. 2017

Datasheet

A2A Adenosine receptors are powerful therapeutic targets especially found in the treatment of such conditions as insomnia, pain, depression, and Parkinson’s disease.

A2A GPCR Adenosine Receptors Class A

A2A GPCR Adenosine Receptors Class A

Background

More Details

More Information

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