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Overview
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ANXA1 EphA2 interaction blocker.
A11 is a peptide derived from amino acid residues 20-30 of the ANXA1 N-terminus fused to the cell penetrating peptide CPP. A11
blocks ANXA1 competition with the E3 ubiquitin ligase Cbl for binding EphA2, enhancing ?Cbl-mediated EphA2 ubiquitination and degradation, and reducing the oncogenic mechanism of the ANXA1 EphA2 interaction in nasopharyngeal carcinoma (NPC). A11 can suppress NPC cell growth in vitro and in vivo.
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Overview