Piperlongumine

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism.
- Properties
  - Categories
    
    Inducer of cell-death
    
    Alternative Name
    
    1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one
    
    CAS Number
    
    20069-09-4
    
    Molecular Formula
    
    C17H19NO5
    
    Molecular Weight
    
    317.34
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥10.45 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O
    
    * For Research Use Only
- Reference
  - 1. Chen D, Ma Y, et al. "Two Natural Alkaloids Synergistically Induce Apoptosis in Breast Cancer Cells by Inhibiting STAT3 Activation." Molecules. 2020;25(1):216. PMID:31948057