Name: 2,2-Anhydrouridine
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- Overview
  - The nucleophilic opening of 2,2-Anhydrouridine represents a novel synthetic approach for elaborating the ring of nucleosides. For example, compounds such as 2’-amino-, 2’-fluoro- and 2’-phenylseleno-2’-deoxyuridines are prepared from the nucleophilic opening of 2,2-Anhydrouridine. 2,2-Anhydrouridine inhibits uridine phosphorylase, a key enzyme targeted by some antitumor drugs.
    
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- Properties
  - Alternative Name
    
    2,2-Anhydro-b-D-arabinofuranosyl uracil;O-2,2-Cyclouridine;2,2-Anhydro-D-uridine
    
    CAS Number
    
    3736-77-4
    
    Molecular Formula
    
    C9H10N2O5
    
    Molecular Weight
    
    226.19 g/mol
    
    MDL Number
    
    MFCD00004945
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Lashkov et al (2010). Structural Basis for the Mechanism of Inhibition of Uridine Phosphorylase from Salmonella typhimurium. Crystallography reports. 55:31-57
    McGee et al (1996). reaction of anhydronucleosides with magnesium alkoxides: reglospeclflc synthesis of 2-O-alkylpyrimidine nucleosides. Nucleosides&Nucleotides 15:1797-1803
    Mcgee (1996). Novel ucleosides via Intramolecular Functionalization of 2,2-Anhydrouridine Derivatives. Tetrahedron Letters. 37:1995-1998