Umirolimus

- Overview
  - Umirolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group, providing one of most hydrophobic tacrolimus analogues. Umirolimus has been targeted for use in stents and medical devices to suppress localised immunoreaction. Umirolimus is extensively cited in the literature with over 70 citations.
    
    Umirolimus is soluble in ethanol, methanol, DMF and DMSO.
    
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    Background
    
    Umirolimus binds to receptor protein, FKBP12. The complex then binds to mTOR and prevents it from interacting with target proteins.
- Properties
  - CAS Number
    
    851536-75-9
    
    Molecular Formula
    
    C55H87NO14
    
    Molecular Weight
    
    986.3
    
    Appearance
    
    White solid
    
    Storage
    
    -20°C
    
    * For research use only