Name: Tumor Necrosis Factor (TNF alpha) human (RECOMBINANT)
Price: 450.00 USD

- Overview
  - Human Tumor necrosis factor (TNF- alpha), also known as Cachectin, is a cytokine composed of 157 amino acid residues, having a molecular weight of 17 kDa (monomer). There is 79% homology between human and murine TNF- alpha, including conserved cysteine residues which form an intrachain disulfide bridge. Biological effects of this cytokine include antitumor activity in vivo and in vitro, activation of polymorphonuclear leukocytes, antiviral activity, and the induction of the release if Interleukin-1 or colony stimulating factors from a variety of sources. Human TNF- alpha (Cachectin) is produced in genetically engineered yeast, and purified by sequential chromatography.
    
    Please contact us at for specific academic pricing.
- Properties
  - Type
    
    Recombinant Proteins
    
    Purification
    
    Over 95% pure by SDS gel electrophoresis.
    
    Formulation
    
    At concentration of 1 mg/ml in 0.02M Tris-HCl/ 0.15 M NaCl (pH 8.0)
    
    Storage
    
    Store at -80°C.
    
    Molecular Weight
    
    17 KDa
    
    Activity
    
    The cell cytolytic activity is determined in the L929 cells (3 x 104 cells/assay) and it is 2-4 x 108 U/mg.
    
    * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.
- Reference
  - 1. Feinstein, R., Kanety, H., Papa, M.Z., lunenfeld, B., and Karasik, A., (1993) The Journal of Biological Chemistry, Vol 268, No. 35, December, 26055-26058
    2. Kalthoff, H., Roeder, C., Brockhaus, M., Thiele, H.G., and Schmiegel, W., (1993) The Journal of Biological Chemistry, Vol 268, No. 4, February, 2762-2766
    3. Chaturvedi, M.M. et al. (1994). J. Biol Chem. 269, 14575-1458

Tumor Necrosis Factor (TNF alpha) human (RECOMBINANT)

Tumor Necrosis Factor (TNF alpha) human (RECOMBINANT)

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