Thiol-dPEG®₄-acid

Thiol-dPEG®4-acid, product number 10247, is a sulfhydryl-containing, crosslinking PEGylation reagent that has a cross-bridge of monodisperse polyethylene glycol. The sulfhydryl end of the crosslinker reacts with gold (forming dative bonds) and with thiol-reactive functional groups such as maleimide, bromoacetyl, SPDP, and thiol. The carboxylic acid end of the molecule couples to free amines using EDC or any suitable carbodiimide. An acylating agent such as N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) can enhance coupling efficiency. The carboxylate must react after the sulfhydryl conjugation.

PEGylation with dPEG® Reagents
OurdPEG® products differ considerably from conventional PEGylation reagents. Traditional PEGylation reagents are disperse polymers. Even PEG with a dispersity (Ð) as low as 1.05 has a large number of different molecular weights and chain lengths of PEG present in the "pure" product. In contrast, our products are entirely monodisperse PEG products, which is why we sell them under the dPEG® tradename.

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