Thiol-dPEG®₁₂-acid

Thiol-dPEG®12-acid, product number 10850, is a single molecular weight, discrete-length polyethylene glycol (dPEG®) crosslinking PEGylation reagent. One end of the crosslinker terminates in a sulfhydryl (thiol) group. Propionic acid terminates the opposite end. The thiol end of the molecule forms dative bonds with gold. Moreover, it forms thioether bonds with maleimide and bromoacetate groups and disulfide bonds with other sulfhydryl groups. The propionic acid group reacts with amines to form amide bonds. Alternatively, if it is left unreacted, the propionic acid group provides a negative charge to the conjugated molecule or modified surface.

OurdPEG® PEGylation Reagents
For over 20 years, Quanta BioDesign has designed, developed, and manufactured monodispersed PEGylation reagents. Unlike typical monodispersed PEGylation reagents, at Quanta BioDesign, we synthesize our products from high purity starting materials. All of our products have single molecular weights and discrete chain lengths (hence the tradename "dPEG®"). Even through multiple synthetic steps, our products retain a uniform composition.

Please contact us at for specific academic pricing.