Thiol-dPEG®₈-acid

Thiol-dPEG®8-acid, product number 10183, is a water-soluble crosslinker containing a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain. A sulfhydryl group and a propionic acid group form the linker's two termini. The sulfhydryl moiety reacts with other sulfhydryls, maleimido groups, the SPDP reactive group, bromoacetamido groups, and gold. Reactions of Thiol-dPEG®8-acid with sulfhydryls or SPDP form disulfide bonds. With maleimido and bromoacetamido compounds, Thiol-dPEG®8-acid reacts to form thioether linkages. Gold forms dative bonds with the sulfhydryl group on Thiol-dPEG®8-acid. The propionic acid moiety couples with free amines to form amide bonds.

PEGylation with dPEG® Products
PEGylation is the process of adding polyethylene glycol (PEG) to molecules or surfaces such as metal, silica, carbon nanoparticles, and glass. Traditional PEG products are disperse polymers. Disperse polymers contain a complex mixture of different polymer chains. Each chain has a different molecular weight. Thus, accurate analysis of such combinations of chain lengths is complicated. Monodisperse PEG products typically are purified from a disperse PEG mixture.

OurdPEG® products are synthesized as small molecules from high purity starting materials. Therefore, our products have no dispersity. In each product, there is but a single, discrete PEG chain with uniform molecular weight. We sell our products under the dPEG® tradename to avoid confusion with the polymeric process implied by the term "monodisperse PEG."

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