Tertiapin LQ

Tertiapin LQ

Catalog Number:
P004516936LIF
Mfr. No.:
PEPTIDE-KC-030
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  • Size:
    1mg
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      • Overview

        • Selective Kir1.1 blocker.
          Tertiapin LQ is a selective blocker of Kir1.1 channels, obtained by modifying tertiapin, the toxin from the honey bee venom. Tertiapin LQ blocks Kir1 with high affinity (1.1 nM) and high selectivity (>250-fold) over many commonly studied Kir subtypes. Application of tertiapin LQ locally in the superficial layers of the cerebellar cortex in decerebrate ferrets suppresses normal performance of Purkinje cell pause responses to the conditional stimulus with no detectable effect on spontaneous firing.

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      • Properties
        • Categories
          Peptides
          Alternative Name
          TPNLQ, TLQ
          Molecular Formula
          C106H179N33O24S4
          Molecular Weight
          2428.03
          Appearance
          Freeze dried solid
          Purity
          >95% by HPLC
          Solubility
          Soluble to 2 mg/ml in 20% acetonitrile / water
          Other Properties
          Sequence: H-Ala-Leu-Cys*-Asn-Cys*-Asn-Arg-Ile-Ile-Ile-Pro-Leu-Gln-Cys*-Trp-Lys-Lys-Cys*-Gly-Lys-Lys-NH2; disulfide bridges between cysteines 3 – 14 and 5 – 18,ALCNCNRIIIPLQCWKKCGKK-NH2
          Modification: Disulfide bridges between cysteines 3 – 14, and 5 – 18, C-terminal amide
          Storage
          Store dry, frozen and in the dark

          * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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