Tertiapin Q

Tertiapin Q

Catalog Number:
P004516937LIF
Mfr. No.:
PEPTIDE-KC-010
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  • Size:
    1mg
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      • Overview

        • Inward rectifier K+ ?channel blocker.
          Tertiapin-Q is a high affinity blocker of inward-rectifier K+ channels. Tertiapin-Q is a stable derivative of the bee venom toxin tertiapin where the methionine residue at position 13 has been replaced with glutamine, which is far less susceptible to oxidation by air. Tertiapin-Q and native tertiapin have very similar pharmacologucal properties. Tertiapin-Q also binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and shows selectivity over Kir2.1 channels.

          Please contact us at for specific academic pricing.

      • Properties
        • Categories
          Peptides
          Alternative Name
          TPNQ, TPN(Q)
          Molecular Formula
          C106H175N35O24S4
          Molecular Weight
          2452
          Appearance
          Freeze dried solid
          Purity
          >95% by HPLC
          Solubility
          Soluble to 2 mg/ml in water
          Other Properties
          Sequence: H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2: disulphide bridges between Cys-3 and Cys-14 and Cys-5 and Cys-18,ALCNCNRIIIPHQCWKKCGKK-NH2
          Modification: Disulphide bridges between C-3 and C14 and C-5 and C-18, Lys-21 is a C-terminal amide
          Storage
          Store dry, frozen and in the dark

          * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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