Name: TIP
Price: 257.00 USD

- Overview
  - TRPV1 inhibitor.
    TIP, or TRPV1 inhibitory peptide (TIP) is a TRPV1 inhibitor corresponding to amino acids 701-709 of the TRPV1 receptor, with Thr705 included as a key component as phosphorylation of this residue causes conformational change and opening of the TRPV1 channel. In cell lines, TIP effectively inhibits capsaicin induced calcium influx and TRPV1 activation and treatment of the immortalised human keratinocyte cell line HaCaT with TIP prevents UV induced increases of MMP-1 and pro-inflammatory cytokines. In mouse skin, TIP inhibits UV induced skin thickening and prevents UV induced expression of MMP-13 and MMP-9. TIP can also attenuate UV induced erythema and the expression of MMP-1, MMP-2, IL-6, and IL-8 in human skin in vivo.
    
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- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    TRPV1 inhibitory peptide
    
    Molecular Formula
    
    C44H79N13O15
    
    Molecular Weight
    
    1029.58
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr-OH,QRAITILDT
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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