Name: Tertiapin
Price: 412.00 USD

- Overview
  - Selective IKACh blocker.
    Tertiapin is a peptide found in the venom of the European honey bee (Apis mellifera). Tertiapin is a selective inhibitor of the G-protein-gated atrial K+ channel IKACh that can prolong atrial effective refractory period and terminate atrial fibrillation. Tertiapin is also a selective and potent inhibitor of muscarinic K+ channels in rabbit cardiac myocytes. The methionine residue at position 13 of tertiapin is sensitive to oxidation, reducing ability to block ion channels, so the methionine may be substituted by glutamine in order to prevent oxidation, resulting in tertiapin-Q, which shows no functional chan and is a more suitable research tool for some applications.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    TPN
    
    Molecular Formula
    
    C106H176N34O23S5
    
    Molecular Weight
    
    2455.07
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water to 1 mg/m
    
    Other Properties
    
    Sequence: H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Met-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2; disulphide bridges between Cys-3 and Cys-14 and Cys-5 and Cys-18,ALCNCNRIIIPHMCWKKCGKK-NH2
    Modification: Disulphide bridges between C-3 and C14 and C-5 and C-18, Lys-21 is a C-terminal amide
    
    Storage
    
    Store dry, frozen and in the dark. Protect from air.
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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