Name: Tat-D3S2
Price: 386.00 USD

- Overview
  - DIRAS3 – beclin1 interaction inhibitor.
    Tat-D3S2 is a peptide derived from the sequence of the switch II region of the small GTPase DIRAS3, conjugated with the HIV-1 Tat protein transduction domain to enhance cellular permeability. DIRAS3 can induce autophagy and plays an important role in forming the autophagosome initiation complex (AIC) with beclin1. In disease states autophagy can protect cancer cells from acute starvation and enhance resistance to chemotherapy. Due to similarity to the binding region of DIRAS3, Tat-D3S2 can bind to beclin 1 and inhibit the beclin1 – DIRAS3 interaction necessary for the induction of autophagy, and in ovarian cancer cells where autophagy is induced by amino acid deprivation, Tat-D3S2 significantly inhibits cell viability.
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Cell Penetrating Peptides
    
    Alternative Name
    
    DIRAS3 switch II-derived peptide, TatD3S2
    
    Molecular Formula
    
    C144H255N65O39
    
    Molecular Weight
    
    3521.02
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Ser-Lys-Ser-Gly-Asp-Gly-Asn-Arg-Ala-Leu-Gln-Arg-His-Val-Ile-Ala-Arg-OH,YGRKKRRQRRRGGSKSGDGNRALQRHVIAR
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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