Name: TAT-GluR6-9c
Price: 298.00 USD

- Overview
  - GluR6-PSD95 interaction blocker.
    TAT-GluR6-9c is a peptide derived from the nine C terminal residues of the kainate receptor subunit GluR6, linked to the cell penetrating sequence TAT. TAT-GluR6-9c ?is able to perturb the interaction of GluR6 with postsynaptic density protein 95 (PSD-95) and suppress the assembly of the GluR6-PSD-95-mixed lineage protein kinase 3 (MLK3) signalling module, causing inhibition of c-Jun N-terminal kinase (JNK) activation. JNK has an important role during global and focal cerebral ischemia/reperfusion and consistent with JNK inhibition, TAT-GluR6-9c pretreatment decreases neuronal death induced by kainate in vitro. In vivo, TAT-GluR6-9c protects against kainate-induced epileptic seizure and has a neuroprotective effect against ischaemic brain damage, significantly decreasing neuronal degeneration.
    
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- Properties
  - Categories
    
    Cell Penetrating Peptides
    
    Alternative Name
    
    Tat-GluR6-9c
    
    Molecular Formula
    
    C106H191N45O26S
    
    Molecular Weight
    
    2542.47
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in saline
    
    Other Properties
    
    Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Leu-Pro-Gly-Lys-Glu-Thr-Met-Ala-OH,YGRKKRRQRRRRLPGKETMA
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

TAT-GluR6-9c

TAT-GluR6-9c

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