Name: TAT-D1 peptide
Price: 397.00 USD

- Overview
  - D1-D2 heteromer antagonist.
    Tat-D1 peptide is a peptide constructed from amino acids 396 413 of the dopamine D1 receptor C tail – a sequence chosen to include amino acids 404Glu and 405Glu which were identified to interact with the dopamine D2 receptor – fused at the NH2 terminus to TAT peptide for cell permeability. TAT-D1 peptide blocks the interaction between D1 and D2 receptors, inhibiting D1-D2 heteromer expression and function without affecting other receptor oligomers such as D1-D1 homomers or D2-D5 heteromers. Tat-D1 peptide disruption of the D1-D2 heteromer abolishes its interaction with Gq and attenuates its calcium signalling and functions as a selective antagonist in vitro and in vivo. In animal models, TAT-D1 treatment alleviates behavioural despair symptoms and exerts antidepressant-like effects in rats, and in addiction models the Tat-D1 peptide reverses SKF83959-induced inhibition of amphetamine sensitization.
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Cell Penetrating Peptides
    
    Alternative Name
    
    D1 peptide
    
    Molecular Formula
    
    C144H257N57O43
    
    Molecular Weight
    
    3472.97
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in saline
    
    Other Properties
    
    Sequence: Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Gln-Gly-Ser-Ser-Glu-Asp-Leu-Lys-Lys-Glu-Glu-Ala-Ala-Gly-Ile-Ala-Arg-Pro-Leu,GRKKRRQRRRPQGSSEDLKKEEAAGIARPL
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

We Also Recommend

Tat-D3S2

$381

TAT-Gap19

$298

TAT-GluR6-9c

$298