Name: TAT-D1 peptide
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- Overview
  - D1-D2 heteromer antagonist.
    Tat-D1 peptide is a peptide constructed from amino acids 396 413 of the dopamine D1 receptor C tail – a sequence chosen to include amino acids 404Glu and 405Glu which were identified to interact with the dopamine D2 receptor – fused at the NH2 terminus to TAT peptide for cell permeability. TAT-D1 peptide blocks the interaction between D1 and D2 receptors, inhibiting D1-D2 heteromer expression and function without affecting other receptor oligomers such as D1-D1 homomers or D2-D5 heteromers. Tat-D1 peptide disruption of the D1-D2 heteromer abolishes its interaction with Gq and attenuates its calcium signalling and functions as a selective antagonist in vitro and in vivo. In animal models, TAT-D1 treatment alleviates behavioural despair symptoms and exerts antidepressant-like effects in rats, and in addiction models the Tat-D1 peptide reverses SKF83959-induced inhibition of amphetamine sensitization.
    
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- Properties
  - Categories
    
    Cell Penetrating Peptides
    
    Alternative Name
    
    D1 peptide
    
    Molecular Formula
    
    C144H257N57O43
    
    Molecular Weight
    
    3472.97
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in saline
    
    Other Properties
    
    Sequence: Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Gln-Gly-Ser-Ser-Glu-Asp-Leu-Lys-Lys-Glu-Glu-Ala-Ala-Gly-Ile-Ala-Arg-Pro-Leu,GRKKRRQRRRPQGSSEDLKKEEAAGIARPL
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

TAT-D1 peptide

TAT-D1 peptide

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