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TAT-Gap19

TAT-Gap19

Catalog Number:
P004516714LIF
Mfr. No.:
PEPTIDE-GJ-040
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  • Size:
    1mg
    Quantity:
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      • Overview

        • Connexin43 hemichannel inhibitor.
          TAT-Gap19 is a connexin43 (Cx43) hemichannel blocker, with an IC50 of 7 μM and no significant affinity for gap junctions or Panx1 channels. TAT-Gap19 is derived from Gap19, a sequence present on the intracellular cytoplasmic loop domain of Cx43, linked to the HIV-derived TAT internalization sequence to promote membrane permeability, which also allows brain penetration. In mouse models of liver damage, TAT-Gap19 can protect against liver fibrosis accompanied by superoxide dismutase overactivation and reduces production of inflammatory proteins.

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          Please contact us at for specific academic pricing.

      • Properties
        • Categories
          Cell Penetrating Peptides
          Molecular Formula
          C119H212N46O26
          Molecular Weight
          2703.28
          Appearance
          Freeze dried solid
          Purity
          >95% by HPLC
          Solubility
          Soluble to 1 mg/ml in water
          Other Properties
          Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Lys-OH,YGRKKRRQRRRKQIEIKKFK
          Storage
          Store dry, frozen and in the dark

          * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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