Name: T2857W
Price: Inquiry

- Overview
  - KIX-MLL interaction inhibitor.
    T2857W is a kinase-inducible domain interacting (KIX) inhibitor designed from a peptide fragment corresponding to the transactivation domain (TAD) of the transcriptional activator, mixed-lineage leukemia protein (MLL). The KIX domain is an integral part of the general transcriptional coactivator CREB binding protein, and has been associated with leukemia, cancer, and various
    viral diseases. KIX is a small globular domain with two binding sites, the c-Myb site and MLL site, which bind the transcriptional activators c-Myb and MLL, respectively. T2857W is the mutant of the MLL TAD peptide identified as having the highest binding affinity for KIX from a series, with a two-fold higher affinity for KIX than the wild-type MLL, and is effective in inhibiting the KIX-MLL interaction. T2857W also shows some selectivity for the MLL-KIX interaction over the c-Myb-KIX interaction.
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    T2857W mutant of the MLL TAD peptide
    
    Molecular Formula
    
    C68H101N15O19S
    
    Molecular Weight
    
    1463.71
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Pro-Ser-Asp-Ile-Met-Asp-Phe-Val-Leu-Lys-Asn-Trp-OH,PSDIMDFVLKNW
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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