Synthetic Ovalbumin mRNA

The synthetic Ovalbumin mRNA (OVA mRNA) expresses the ovalbumin protein when transfected into mammalian cells. The codons of Ovalbumin mRNA are optimized for mammalian expression with the depletion of U bases. It has a cap-1 structure and a long polyA120 tail. The unmodified, synthetic Ovalbumin mRNA activates the innate immune system and production of cytokines, which will influence the overall induced immune response. We also offer N1-methylpseudouridine modified Ovalbumin mRNA that can reduce the innate immune response.

Ovalbumin is a chicken protein allergen mainly found in egg white. It is commonly used to sensitize immune reactions. As a heterologous gene, Ovalbumin mRNA may promote the growth and proliferation of immune cells, thereby enhancing the host’s anti-tumor and anti-viral ability. Expression of Ovalbumin mRNA in bone marrow-derived dendritic cells results in prominent OVA-specific cytotoxic T lymphocyte activity in vivo and antitumor effects. Moreover, nanoparticle encapsulated OVA mRNA reduced the tumor growth rate in lymphoma-bearing mouse models.

• Codon-optimized for expression in mammalian cells
• U-depletion
• 5′- m7G cap (Cap-1)
• Long polyA120 tail

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