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Overview
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The Modified Ovalbumin mRNA (m1Ψ) has a 100% substitution of the modified nucleotide N1-methylpseudouridine, which enhances the translation and reduces the innate antiviral response to single-stranded mRNA.
Ovalbumin is a chicken protein allergen that is commonly found in egg white. It is typically used to sensitize immune reactions. As a heterologous gene, Ovalbumin mRNA may promote the growth and proliferation of immune cells, enhancing the host’s anti-tumor and anti-viral ability. Expression of Ovalbumin mRNA in bone marrow-derived dendritic cells results in prominent OVA-specific cytotoxic T lymphocyte activity in vivo and antitumor effects. Moreover, nanoparticle encapsulated OVA mRNA reduces the tumor growth rate in lymphoma-bearing mouse models.
• Codon-optimized for expression in mammalian cells
• U-depletion
• 5′- m7G cap (Cap-1)
• Long polyA120 tail
• 100% substitution of N1-methylpseudouridinePlease contact us at for specific academic pricing.
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