Name: RS17
Price: 298.00 USD

- Overview
  - CD47 – SIRP signalling inhibitor.
    RS17 is a peptide which binds to the transmembrane protein CD47 and blocks the interaction of CD47 with the regulatory membrane glycoprotein signal regulatory protein (SIRP?). In normal cells, CD47 interaction with SIRP on the macrophage surface membrane sends a phagocytosis inhibiting signal, a mechanism which can be taken advantage of by cancer cells to enable immune escape. RS17 blockade of the CD47 and SIRP? interaction in cancer cells can prevent phagocytosis evasion, and treatment with RS17 significantly promotes the removal of tumour cells by macrophages. RS17 has a strongly inhibitory effect on tumour growth in a cancer xenograft mouse model.
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Protein-Protein Interaction Modulators
    
    Molecular Formula
    
    C96H131N31O25
    
    Molecular Weight
    
    2119.28
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Other Properties
    
    Sequence: H-Arg-Arg-Tyr-Lys-Gln-Asp-Gly-Gly-Trp-Ser-His-Trp-Ser-Pro-Trp-Ser-Ser-NH2,RRYKQDGGWSHWSPWSS-NH2
    Modification: C terminal amide
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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