Name: SMRwt
Price: 331.00 USD

- Overview
  - Disrupts the Nef-mortalin interaction, anti-metastatic.
    SMRwt is derived from the secretion modification region (SMR, amino acids 66 to 70) of the HIV-1 Nef protein. Nef is a 27-kDa protein produced early during HIV infection of a cell, which interacts with mortalin, a member of the heat shock 70-kDa protein family via Nef’s SMR motif, an interaction which is disrupted by the SMRwt peptide. In breast cancer cells SMRwt interacts with mortalin and also the structural protein vimentin to inhibit pro-epithelial-mesenchymal transition (EMT) exosome release, and induce EMT tumour suppressor protein expression. Exosomes containing EMT programs transmit pro-metastatic phenotypes and SMRwt peptide treatment results in an effective blockade of breast cancer cell migration.
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Protein-Protein Interaction Modulators
    
    Alternative Name
    
    Secretion modification region peptide, SMR peptide, Wildtype-3
    
    Molecular Formula
    
    C99H144N22O32
    
    Molecular Weight
    
    2153.03
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Val-Gly-Phe-Pro-Val-Ala-Ala-Val-Gly-Phe-Pro-Val-Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys-OH,VGFPVAAVGFPVDYKDDDDK
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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