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TPP-1

TPP-1

Catalog Number:
P004516988LIF
Mfr. No.:
PEPTIDE-PP-280
Price:
$298
  • Size:
    1mg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • Blocks PD-1/PD-L1 interaction.
          TPP-1 is a peptide identified through bacterial surface display which binds specifically to programmed cell death ligand 1 (PD-L1), and blocks programmed cell death protein 1 (PD-1)/PD-L1 interaction. TPP-1 binds to free PD-L1 and also cells that express PD-L1 on their cell membranes, and can reverse PD-L1 mediated inhibition of T-cell activation, and inhibit human tumour growth via a T-cell dependent mechanism. In xenograft mouse models, tumour growth in TPP-1 treated mice was 56% – 71% lower than that in controls.

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          Please contact us at for specific academic pricing.

      • Properties
        • Categories
          Protein-Protein Interaction Modulators
          Alternative Name
          Targeting PD-L1 peptide, TPP-1 peptide
          Molecular Formula
          C107H150N34O32S2
          Molecular Weight
          2488.67
          Appearance
          Freeze dried solid
          Purity
          >95% by HPLC
          Other Properties
          Sequence: H-Ser-Gly-Gln-Tyr-Ala-Ser-Tyr-His-Cys-Trp-Cys-Trp-Arg-Asp-Pro-Gly-Arg-Ser-Gly-Gly-Ser-Lys-OH,SGQYASYHCWCWRDPGRSGGSK
          Storage
          Store dry, frozen and in the dark

          * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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