Protein Deruxtecan Conjugation Kit

This kit for label any protein (≥20 KDa) with Deruxtecan. Deruxtecan is an exatecan-derivative topoisomerase I inhibitor (DXd) with an enzymatically cleavable peptide linker GGFG (Nakada, T. et. al. Bioorg. Med. Chem. Lett. 2016, 26, 1542−1545). The user supplies the antibody. The kit includes Deruxtecan with an maleimide active group, which can be coupled directly to the antibody after reduction through alkylation in a single step. The product is purified to remove any unreacted drugs.

Kit is configured to conjugate 6.67-20 nano-mole (nmol) of one (CM11432x1) or three proteins (CM11432x3).

If you have a smaller amount of protein, a protein with a MW below 20KDa, or other customization needs, please select the customization radio button and/or fill out the information above.

• Drug Information
Name: Deruxtecan (Mc-GGFG-DXd)
Synonym: Exatecan derivative, DX 8951 derivative; DXd; payload for DS-8201a;
CAS number: 1599440-13-7
Chemical formula: C52H56FN9O13
MW: 1034.0684
Mechanism of action: Trastuzumab Deruxtecan, sold under the brand name Enhertu was approved by US FDA for treating metastatic HER2-postive breast cancer.

• Requirement for Protein
Preferably >90% pure by gel electrophoresis
Total amount: 6.67-20 nano-mole (nmol) protein content as measured by UV.

• Key Features of this PerKit™
Offers a simple and easy way to label protein with Deruxtecan with minimal exposure to the toxin
Enzymatic cleavable peptide linker GGFG
Fast and easy preparation: 6 h preparation and <2 hours of hands-on time
All reagents and supplies included for preparation and purification

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