Pitavastatin Calcium

- Overview
  - Pitavastatin Calcium is the calcium salt of Pitavastatin, a compound that inhibits cholesterol synthesis and displays cardioprotective properties. Pitavastatin may be usefully combined with zoledronic acid in cancer therapy.
    
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    Background
    
    Pitavastatin in the enzyme that catalyzes the first step in cholesterol synthesis known as HMG-CoA reductase.
- Properties
  - CAS Number
    
    147526-32-7
    
    Molecular Formula
    
    C50H46F2N2O8 • Ca
    
    Molecular Weight
    
    880.99 g/mol
    
    Appearance
    
    Crystalline powder
    
    Solubility
    
    Water (<1 mg/ml), DMSO (~25 mg/ml), DMF (~30 mg/ml),
    
    Other Properties
    
    Source: synthetic
    
    Storage
    
    ≤30°C
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: Recent lab results have suggested that Pitavastatin is superior to other statins for use in oncology because it is the only statin that is both lipophilic, and has a suitably long half-life . Pitavastatin was found to inhibit the growth of ovarian cancer cell cultures. Combinations with zoledronic acid displayed additive or synergistic effects in 10 of 11 cell lines tested (Abdullah et al, 2017).