Mupirocin Calcium

- Overview
  - Mupirocin Calcium is a carboxylic acid bacteriostatic/bactericidal antibiotic produced by Pseudomonas fluorescens. It is used against the bacteria causing impetigo and skin infections. The product can be used for kinetic assays and in susceptibility testing applications.
    
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    Background
    
    Mupirocin inhibits protein synthesis by binding to isoleucyl-tRNA synthetase, an enzyme which conjugates the amino acid isoleucine to its corresponding tRNA.
- Properties
  - CAS Number
    
    115074-43-6
    
    Molecular Formula
    
    C56H86CaO16 • 2H2O
    
    Molecular Weight
    
    1075.34
    
    Solubility
    
    Very sparingly soluble in water
    
    Other Properties
    
    Source: Pseudomonas Fluorescens
    Assay: 865 - 936 µg/mg
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Mupirocin is commonly used to target Gram-positive bacteria especially Methicillin resistant Staphylococcus aureus (MRSA). It is also active against fungi.
    
    Microbiology Applications: Mupirocin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive Staphylococcus microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Methicillin resistant Staphylococcus aureus 0.25 µg/mL – 0.39 µg/mL