pAAVone-sc-AAV-DJ-CMV-EGFP

pAAVone-sc-AAV-DJ-CMV-EGFP is a plasmid used to produce scAAV-DJ-CMV-EGFP using novel AAVone production system. It integrates all the AAV production necessary components, including Ad helper genes (E2A, E4orf6 and VA RNA), AAV helper genes (Rep and AAV-DJ), and a self-complementary AAV-CMV-EGFP genome. scAAV-DJ-CMV-EGFP viruses can be simply and efficiently produced by transfection of this single-into host cells, such us HEK 293 and HEK 293T. AAV-DJ is a synthetic, hybrid adeno-associated virus serotype engineered to combine the advantageous properties of several naturally occurring AAV serotypes. It was created by shuffling the capsid genes from multiple serotypes (including AAV2, AAV8, and AAV9, among others) to enhance transduction efficiency and broaden tissue tropism. AAV-DJ is particularly known for its high efficiency in transducing a variety of cell types, including liver, muscle, and neurons, making it a versatile tool in gene therapy research.

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