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Overview
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GPR133 activator.
p13 is a peptide derived from the C-terminal component which starts at the GPCR proteolysis cleavage site of GPR133. p13 specifically activates both generated chimeric P2Y12-CTF(GPR133) receptors and the wild-type GPR133 ?receptor and is an agonist as measured by cAMP accumulation. p13 is highly selective for GPR133, and is a short tethered sequence (the Stachel sequence) within the ectodomain of GPR133, reinforcing that tethered peptide activation is a common signalling modality for the adhesion GPCR class of receptors.
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