Name: P4pal10
Price: 301.00 USD

- Overview
  - PAR4 antagonist.
    P4pal10 is a pepducin with a peptide sequence identical to part of the third intracellular loop of the protease activated receptor 4 (PAR4) which acts as a PAR4 antagonist. P4pal10 has no agonist activity as measured by platelet aggregation, intracellular Ca2+ release or InsP production, but preincubation of human platelets with P4pal10 completely blocks aggregation in response to PAR4 activators. Infusion of P4Pal10 into mice extends bleeding time and protects against systemic platelet activation, and in rat models of myocardial injury, P4pal10 treatment before ischemia significantly decreases infarct size when given before, during, and after ischemia. P4Pal10 also inhibits signalling downstream of the Gi-coupled FPR2.
    
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- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    Pepducin P4Pal10, palmitoyl-SGRRYGHALR-amide, P4pal-10
    
    Molecular Formula
    
    C65H112N22O13
    
    Molecular Weight
    
    1409.72
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in DMSO
    
    Other Properties
    
    Sequence: Pal-Ser-Gly-Arg-Arg-Tyr-Gly-His-Ala-Leu-Arg-NH2,Pal-SGRRYGHALR-NH2
    Modification: C terminal palmitoylation, N terminal amide
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

P4pal10

P4pal10

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