Name: Nystatin
Price: 135.00 USD

- Overview
  - Nystatin is a fungicidal and fungistatic polyene antifungal and growth promoter. It functions by accumulating cholesterol and thereby sequesters lipid from cell membranes. It can be used in quantum dot research, since cholesterol depletion could block several lipid raft-dependent endocytic pathways. It was discoveed in 1950 by Rachel Fuller Brown and Elizabeth Lee Hazen and was the first polyene macrolide antifungal, named after New York State.
    
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    Background
    
    Nystatin binds ergosterol in the fungal cell membrane forming pores and increasing permeability. The altered permeability is toxic to the fungi leading to growth inhibition or death.
- Properties
  - CAS Number
    
    1400-61-9
    
    Molecular Formula
    
    (Nystatin A1) C47H75NO17
    
    Molecular Weight
    
    926.09 (Nystatin A1)
    
    Appearance
    
    Yellow powder
    
    Solubility
    
    Soluble in methanol and ethanol. Sparingly soluble in water.
    
    Other Properties
    
    Source: Streptomyces noursei and Streptomyces aureus
    PH: 6.0 - 8.0
    Assay: (Dried Basis): ≥5000 u/mg
    Loss on Drying: ≤ 5.0%
    Identification: Passes test
    Purity Level: Nystatin A1: ≥85.0%
    
    Storage
    
    -20 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Nystatin primarily targets the cell membrane of Candida species especially those which cause vaginal infections.
    
    Microbiology Applications: Nystatin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against fungal isolates. Medical microbiologists use AST results to recommend treatment options. Representative effective ranges include:
    
    Candida albicans 0.78 µg/mL - 400 µg/mL
    
    Plant Biology Applications: Nystatin can be used in plant tissue culture to control contamination.
    
    Eukaryotic Cell Culture Applications: Nystatin is commonly used to prevent contamination in cell culture.
    Quantum dots can be used to deliver and monitor biomolecules, but the study of the uptake mechanism is just beginning. Researchers found that Nystatin is a highly selective inhibitor of the lipid raft-dependent pathway and the uptake of SR9 is a lipid raft-dependent process, thus it can be a valuable compound for quantum dot research (Xu et al, 2010).
    Nystatin can induce interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in TLR2-expressing THP1 cells.

Datasheet

MSDS

Nystatin

Nystatin

Background

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