Name: Nystatin A1
Price: 183.00 USD

- Overview
  - Nystatin is a fungicidal and fungistatic polyene antifungal and growth promoter, first reported in 1950. It is a complex of A1, A2 and A3. Nystatin functions by accumulating cholesterol and thereby sequesters lipid from cell membranes. It can be used as a bioprobe and in quantum dot research, since cholesterol depletion can block several lipid raft-dependent endocytic pathways.
    Nystatin A1 is soluble in DMF and DMSO, moderately soluble in methanol and ethanol, and sparingly soluble in water.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Nystatin, like most polyene antifungals, binds to sterols in the fungal cell membrane leading to formation of ion channels in the wall, ion imbalance and cell death.
- Properties
  - CAS Number
    
    1400-61-9
    
    Molecular Formula
    
    C47H75NO17
    
    Molecular Weight
    
    926.1
    
    Appearance
    
    Yellow solid
    
    Solubility
    
    Soluble in DMSO and DMF. Moderately soluble in methanol and ethanol. Sparingly soluble in water (0.36 mg/ml).
    
    Other Properties
    
    Source: Streptomyces noursei
    Purity Level: >98% by HPLC
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Microbiology Applications: Nystatin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against fungal isolates. Medical microbiologists use AST results to recommend treatment options. Representative effective ranges include:
    
    Candida albicans 0.78 µg/mL - 400 µg/mL
    
    Plant Biology Applications: Nystatin can be used in plant tissue culture to control contamination. The first few days after protoplast isolation are the most critical in terms of establishing sterile culture. Authors found the most satisfactory control of protoplasts from leaf mesophyll cells was Nystatin (25 U/ml) in combination with carbenicillin (250 µg/ml)(Watts and King, 1973).
    
    Eukaryotic Cell Culture Applications: Nystatin is commonly used to prevent contamination in cell culture.
    Quantum dots can be used to deliver and monitor biomolecules, but the study of the uptake mechanism is just beginning. Researchers found that Nystatin is a highly selective inhibitor of the lipid raft-dependent pathway and the uptake of SR9 is a lipid raft-dependent process, thus it can be a valuable compound for quantum dot research (Xu et al, 2010).
    Nystatin can induce interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in TLR2-expressing THP1 cells.