-
-
Overview
-
Novobiocin Sodium, Granulized is an aminocoumarin antibiotic that prevents cell division. Novobiocin Sodium is freely soluble in aqueous solution and the product has been granulized which enhances its water solubility. This formulation has a significantly larger particle size than Novobiocin Sodium (N014), (average particle size 333.4 µm vs. 0.139 µm) and it is dust-free for an enhanced safety profile.
Please contact us at for specific academic pricing.
Background
Novobiocin Sodium, Granulized is an inhibitor of bacterial DNA gyrase, a topoisomerase which relieves strain as DNA unwinds during replication and transcription. The product also inhibits eukaryotic DNA topoisomerase II (Topo II). By inhibiting these enzymes, Novobiocin blocks DNA synthesis and ultimately causes cell death. The compound is an inhibitor of heat shock protein (Hsp90), interacting with the C-terminal ATP-binding domain of Hsp90. Novobiocin has been described to inhibit retroviral RNA-dependent DNA polymerase and ATP-binding cassette super-family G member 2 (ABCG2).
Researchers found that the GyrB subunit of DNA gyrase is important in the annate resistance of S. saprophyticus to Novobiocin and that G85 and K140 of GyrB are critical for the expression of resistance (Vickers et al, 2007).
-
- Properties
- Applications
-
Overview