Name: Niclosamide ethanolamine salt
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- Overview
  - Chemically a chlorinated salicylanilide, niclosamide is clinically used as an anthelmintic agent. The action of niclosamide has been proven to proceed by inhibiting the STAT3 signaling pathway. Recently, niclosamide, has been considered as an antiproliferative agent in cancer treatment, e.g. melanoma and colorectal cancer. In 2021, niclosamide has been tested for the treatment of COVID-19 patients.
    
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- Properties
  - Alternative Name
    
    Niclosamide-olamine; 2,5-Dichloro-4-nitrosalicyloylanilide ethanolamine salt; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzami de 2-aminoethanol
    
    CAS Number
    
    1420-04-8
    
    Molecular Formula
    
    C15H15Cl2N3O5
    
    Molecular Weight
    
    388.2 g/mol
    
    Note
    
    There is a hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ren et al (2010). Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Medical Chemistry Letterrs, 1(9):454–459.
    Zhirnik et al (2016). Antiproliferative Activity of Niclosamide Against Melanoma and Colorectal Cancer Cells. Pharmaceutical Chemistry Journal, 50:471–474.
    Backer et al (2021). A randomized, double-blind, placebo-controlled phase 1 trial of inhaled and intranasal niclosamide:A broad spectrum antiviral candidate for treatment of COVID-19. The Lancet, 4:100084.