Name: NAF-1 44-67
Price: 331.00 USD

- Overview
  - Targets cancer cell mitochondria and ER.
    NAF-1 44-67 is derived from the transmembrane and flexible loop regions of the human mitochondrial/ER membrane-anchored NEET protein, Nutrient Autophagy Factor 1 (NAF-1), with d amino acid residues incorporated into its sequence to improve stability in biological systems. NAF-1 44-67 selectively permeates through the plasma membranes of human epithelial breast cancer cells and targets their mitochondria and ER, triggering cell death with characteristics of apoptosis, ferroptosis and necroptosis. The specificity of NAF-1 44-67 towards cancer cells is due to it being derived from the NAF-1 sequence that resides in the mitochondrial and ER membranes. In vivo NAF-1 44-67 significantly decreases tumour growth in xenograft mice carrying human triple-negative breast cancer MDA-MB-231 tumours.
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Cell Penetrating Peptides
    
    Alternative Name
    
    3D-NAF-1 44-67
    
    Molecular Formula
    
    C133H219N33O28
    
    Molecular Weight
    
    2726.67
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Phe-Leu-Gly-Val-Leu-Ala-Leu-Leu-Gly-(D)Tyr-Leu-Ala-Val-Arg-Pro-(D)Phe-Leu-Pro-Lys-(D)Lys-Lys-Gln-Gln-Lys-OH,FLGVLALLGyLAVRPfLPKkKQQK
    Modification: Tyrosine 10, phenylalaine 16 and lysine 20 are D amino acids
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

NAF-1 44-67

NAF-1 44-67

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