Monoclonal antibody to human TG2 (Catalytic Domain, clone XTG17)

- Overview
  - Protein G-affinity purified mouse monoclonal antibody.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Tissue transglutaminase is a, Ca2+-dependent enzyme (78 kDa) composed by 4 domains:Beta Sheet Domain (fibronectin binding, ~17 kDa), catalytic Core Domain (Cys-His-Asp catalytic triad, Calcium-binding, GTP/GDP-binding, ~37 kDa), Beta Barrel 1 Domain (GTP/GDP-binding, ~14 kDa) and Beta Barrel 2 Domain (~12 kDa). The inactive GTP-bound enzyme is present in a closed conformation, which upon activation by Ca2+ and substrate binding opens like a pocket knife resulting in a longitudinal open conformation.
- Properties
  - Antibody Type
    
    monoclonal
    
    Reactivity
    
    human
    
    Clone
    
    XTG17
    
    Formulation
    
    liquid
    
    Storage
    
    Store at 2 – 8 °C. Delivery is possible at ambient temperature
    
    Note
    
    Intended for research use only, not for use in human, therapeutic or diagnostic applications.
    
    Antigen
    
    Transglutaminase 2
- Applications
  - Application
    
    WB; IF
- Reference
  - Kanchan et al., Cell. Mol. Life Sci. 2015, 72:3009-35