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Overview
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Protein G-affinity purified mouse monoclonal antibody.
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Background
Tissue transglutaminase is a, Ca2+-dependent enzyme (78 kDa) composed by 4 domains:Beta Sheet Domain (fibronectin binding, ~17 kDa), catalytic Core Domain (Cys-His-Asp catalytic triad, Calcium-binding, GTP/GDP-binding, ~37 kDa), Beta Barrel 1 Domain (GTP/GDP-binding, ~14 kDa) and Beta Barrel 2 Domain (~12 kDa). The inactive GTP-bound enzyme is present in a closed conformation, which upon activation by Ca2+ and substrate binding opens like a pocket knife resulting in a longitudinal open conformation.
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- Properties
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- Reference
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Overview