Mitoxantrone Hydrochloride

- Overview
  - Mitoxantrone Hydrochloride is an anti-cancer agent used chemotherapeutically for leukemias and solid tumors. It has immunosuppressive activity and inhibits proliferation of lymphocytes and induces apoptosis of antigen-presenting T-cells. The compound is sparingly soluble in water.
    
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    Background
    
    Mitoxantrone inhibits division of T-cells, B-cells, and macrophages by preventing DNA repair and synthesis, however, this also occurs in healthy cells. It is a cytostatic anthracenedione that induces double-strand breaks in DNA.
- Properties
  - CAS Number
    
    70476-82-3
    
    Molecular Formula
    
    C22H28N4O6 · 2 HCl
    
    Molecular Weight
    
    517.40
    
    Solubility
    
    Sparingly soluble in water
    
    Other Properties
    
    Source: Synthetic
    Melting Point: 203-205 °C
    Purity Level: ≥98.0%
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: Mitoxantrone is commonly used in cancer research to study breast cancer, leukemia, and non-Hodgkin’s lymphoma.