MitoPeDPP

- Overview
  - MitoPeDPP is a cell-membrane-permeable probe, Perylene-based dye. It specifically localizes in mitochondria due to the triphenylphosphonium moiety introduced. MitoPeDPP is used to monitor lipid peroxidation in ferroptosis research.
    
    Please contact us at for specific academic pricing.
    
    More Details
    
    Cellular Metabolism and Anticancer Effects
    
    Cellular Senescence and Mitochondrial Disfunction Due to Lipid Accumulation
    
    Ferroptosis
    
    Mitochondria Research
- Properties
  - Categories
    
    Lipid Peroxide
    
    Molecular Formula
    
    C53H41IOP2
    
    Molecular Weight
    
    882.74
    
    Appearance
    
    Yellow crystalline powder or solid
    
    Purity
    
    ≥80.0% (HPLC)
    
    Storage
    
    0-5°C, protect from light
    
    Shipping
    
    ambient temperature
    
    * For research use only
- Applications
  - Application
    
    Lipid Peroxide in Mitochondria
- Reference
  - 1) K. Shioji K, Y. Oyama, K. Okuma and H. Nakagawa, "Synthesis and properties of fluorescence probe for detection of peroxides in mitochondria.", Bioorg Med Chem Lett., 2010, 20, (13), 3911.
    
    2) K. Shioji, Y. Ogawa, H. Iwashita, Y. Oyama, N. Nagahora, K. Okuma and H. Nakagawa, ‘’Fluorescence imaging of accumulated lipid peroxidation in mitochondria by oxidative stress’’, Bioorg. Med. Chem, submitted.
    
    3) S. Oka, J. Leon, K. Sakumi, T. Ide, D. Kang, F. M. LaFerla and Y. Nakabeppu, "Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer’s disease", cientific Reports ., 2016, DOI: 10.1038/srep37889 , .
    
    4) S. Nakamura, A. Nakanishi, M. Takazawa, S. Okihiro, S. Urano and K. Fukui, "Ionomycin-induced calcium influx induces neurite degeneration in mouse neuroblastoma cells: Analysis of a time-lapse live cell imaging system", Free Radical Research., 2016, 50, (11), 1214.
    
    5) M. Akimoto, R. Maruyama, Y. Kawabata, Y. Tajima and K. Takenaga, "Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERKdependent necroptosis", Cell Death Dis., 2018, 9, 804.
    
    6) M. Álvarez-Córdoba, A. Fernández Khoury, M. Villanueva-Paz, C. Gómez-Navarro, I. Villalón-García, J. M. Suárez-Rivero, S. Povea-Cabello, M. Mata, D. Cotán, M. Talaverón-Rey, A. J. Pérez-Pulido, J. J. Salas, E. M. Pérez-Villegas, A. Díaz-Quintana, J. A. Armengol, J. A. Sánchez-Alcázar , "Pantothenate Rescues Iron Accumulation in Pantothenate Kinase-Associated Neurodegeneration Depending on the Type of Mutation.", Mol. Neurobiol. ., 2019, 56, (5), 3638.