Meropenem with Sodium Carbonate

- Overview
  - Meropenem with Sodium Carbonate is a salt form of Meropenem, a β-lactam antibiotic in the carbapenem class, which targets the bacterial cell wall. Meropenem has found utility against extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae that are resistant to many β-lactam antibiotics and certain cephalosporins. Meropenem with Sodium Carbonate is very soluble in water.
    
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    Background
    
    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many carbapenems, Meropenem is highly resistant to the degradative effects of β-lactamases.
- Properties
  - Molecular Formula
    
    C17H25N3O5S • Na2CO3
    
    Molecular Weight
    
    466.46
    
    Appearance
    
    White or almost white powder
    
    Solubility
    
    Very soluble in water (112 mg/ml)
    
    Other Properties
    
    PH: 7.3 - 8.3
    Assay: (Dried basis, Meropenem) Not less than 78.0%
    Residue On Ignition: Not more than 0.1%
    Heavy Metals: Not more than 10ppm
    Loss on Drying: 9.0% - 12.0%
    Identification: Passes test
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Meropenem has a broad spectrum of activity and has been found to be effective against extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae; a group of pathogenic microbes resistant to many first line β-lactam antibiotics and certain cephalosporins.
    
    Microbiology Applications: Meropenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Meropenem has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    
    Staphylococcus epidermidis 0.06 µg/mL - 16 µg/mL
    Neisseria meningitis 0.002 µg/mL – 0.03 µg/mL
    
    Media Supplements
    Meropenem can be used as a selective agent in several types of isolation media:
    VRE Medium - VRE Selective Supplement
    
    Plant Biology Applications: Meropenem can be used to suppress the overgrowth of Agrobacterium in tobacco, tomato, and rice transformation, with 25 mg/L suppressing outgrowth (Ogawa and Mii , 2007). Meropenem suppressed growth of Agrobacterium during transformation of Phalaenopsis at 5 mg/L and had no phytotoxic effect on the cells themselves (Sjahril and Mii, 2005).