Meropenem Vaborbactam (1:1 mixture)

- Overview
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    Background
    
    Meropenem penetrates the bacterial cell wall and binds penicillin-binding protein (PBP) and inhibits the cross-linking of peptidoglycan chains leading to cell lysis and death. It is stable in the presence of many beta-lactamases due to its 6-trans-hydroxyethylgroup. Vaborbactam alone has no antibacterial activity . The addition of the boronate ester improves substrate activity against beta-lactamases. Vaborbactam protects Meropenem from degradation by certain serine beta-lactamases such as Klebsiella pneumoniae carbapenemase (KPC). When in combination, the antimicrobial activity is similar to meropenem.
    Resistance may involve porin mutations combined with overexpression of efflux pumps, but research has shown variable results.
- Properties
  - CAS Number
    
    2031124-72-6
    
    Molecular Formula
    
    C17H25N3O5S x 3H20; C12H16BNO5S
    
    Molecular Weight
    
    437.52 (Meropenem Trihydrate); 297.14 (Vaborbactam)
    
    Appearance
    
    White or light yellow powder
    
    Solubility
    
    Sparingly soluble in water
    
    Other Properties
    
    Source: Synthetic
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Meropenem Vaborbactam is active against Gram-positive and Gram-negative bacteria including carbapenem-resistant Enterobacteriaceae (CRE). It is also effective against E. coli, Klebsiella pneumoniae, and Enterobacter cloacae species complex.
    
    Microbiology Applications: Meropenem Vaborbactam is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) such as Oxoid discs, Sensititre, and eTEST. Medical microbiologists use AST results to recommend antibiotic treatment options.