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MD-224

MD-224

Catalog Number:
PTC1441523INV
Mfr. No.:
V31651
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      • Overview

        • MD-224 is a novel, first-in-class and potent PROTAC molecule targeting human murine double minute 2 (MDM2) for degradation, it has the potential to be used as a new class of anticancer agent. It is able to induce rapid degradation of MDM2 protein at a concentration of<1 nM in human leukemia cells, and has an antiproliferative IC50 value of 1.5 nM for inhibiting the growth of RS4;11 cells.

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      • Properties
        • Categories
          PROTACs
          CAS Number
          2136247-12-4
          Molecular Formula
          C48H43CL2FN6O6
          Molecular Weight
          889.8
          Purity
          ≥98%
          Storage
          Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
          In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months
          Shipping
          Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
          SMILES
          FC1=C(Cl)C=CC=C1[C@@H]2[C@@]3(C(C=CC(Cl)=C4)=C4NC3=O)C5(CCCCC5)N[C@H]2C(NC6=CC=C(C(NCCCC#CC7=C(CN(C8C(NC(CC8)=O)=O)C9=O)C9=CC=C7)=O)C=C6)=O

          * For research use only

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