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MZ1

MZ1

Catalog Number:
PTC1441524INV
Mfr. No.:
V3580
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      • Overview

        • MZ 1 (MZ1; MZ-1) is a novel and potent PROTAC-based degrader of BRD4 protein with anticancer activity. Inducing macromolecular interactions with small molecules to activate cellular signaling is a challenging goal. PROTACs (proteolysis-targeting chimeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucidation of the key ternary ligase-PROTAC-target species and its impact on target degradation selectivity remain elusive.

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      • Properties
        • Categories
          PROTACs
          CAS Number
          1797406-69-9
          Molecular Formula
          C49H60CLN9O8S2
          Molecular Weight
          1002.64
          Purity
          ≥98%
          Storage
          Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
          In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months
          Shipping
          Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
          SMILES
          O=C([C@H]1N(C([C@@H](NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2)=O)=O)C(C)(C)C)=O)CCC1)NCC6=CC=C(C7=C(C)N=CS7)C=C6

          * For research use only

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