Name: Mca-SEVNLDAEFR-K(Dnp)-RR-NH2
Price: 298.00 USD

- Overview
  - FRET substrate for beta-secretase 1 (BACE-1).
    Mca-SEVNLDAEFR-K(Dnp)-RR-NH2, also knowm as Mca-(Asn ¶ · °,Leu ¶ · ¹)-Amyloid ?/A4 Protein Precursor ‚‡ ‚‡ ‚ (667-676)-Lys(Dnp)-Arg-Arg amide, is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the ‘Swedish’ Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) ?-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Fluorescent Labelled Peptides
    
    Molecular Formula
    
    C86H125N27O29
    
    Molecular Weight
    
    2001.1
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in DMSO
    
    Other Properties
    
    Sequence: Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2,Mca-SEVNLDAEFR-K(Dnp)-RR-NH2
    Modification: 7-methoxycoumarin (Mca) at N terminal, 2,4-dintrophenyl on lysine 11, C terminal amide
    
    Storage
    
    Store desiccated, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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