Name: MOTS-c
Price: 298.00 USD

- Overview
  - AMPK activator.
    MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame (sORF) within the mitochondrial 12S RNA. MOTS-c, which is a contraction of mitochondrial open reading frame of the 12S rRNA-c, regulates insulin sensitivity and metabolic homeostasis with its primary target organ being skeletal muscle. The cellular action of MOTS-c is to inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to activation of AMP-activated protein kinase (AMPK), a central regulator of energy homeostasis. In mouse models, MOTS-c treatment prevents age dependent and high fat diet-induced insulin resistance, as well as diet induced obesity.
    
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- Properties
  - Categories
    
    Kinase Modulators
    
    Alternative Name
    
    Mitochondria-derived peptide MOTS-c, Mitochondrial open reading frame of the 12S rRNA-c
    
    Molecular Formula
    
    C101H152N28O22S2
    
    Molecular Weight
    
    2174.62
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH,MRWQEMGYIFYPRKLR
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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