m-dPEG®₁₂-amine

m-dPEG®12-amine, product number 10288, is a non-immunogenic, water-soluble chemical modification reagent. The product contains a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain. The dPEG® chain terminates on one end with a methyl group and the other end with an amine. The amino group reacts with carboxylic acids (and their active esters), aldehydes, and ketones. Reacting the amino group with aldehydes or ketones forms a labile imine (Schiff base). Reacting carboxylic acids or their active esters with m-dPEG®12-amine forms stable amide bonds. Uses for this product include passivating surfaces and coating biomolecules.

PEGylation with dPEG® Products
PEGylation is the process of modifying surfaces, small molecules, and biomolecules such as peptides or proteins, with polyethylene glycol (PEG). Conventional PEG reagents are disperse polymers. Polymer dispersity complicates the analysis of conjugates created with them. Our dPEG® products have no dispersity. Instead, each dPEG® product contains a discrete chain length of PEG with a single molecular weight

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