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Overview
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LwaCas13a (previously known as LwaC2c2) is a crRNA-mediated RNA endonuclease derived from Leptotrichia wadeim. It can specifically recognize and cleave the RNA target with the PFS sequence. In addition, Cas13a also has the trans-cleavage activity, that is, when LwaCas13a binds crRNA and RNA target to form a ternary complex, it releases the trans-cleavage activity of Cas13a against non-target ssRNA sequences. This activity has also been applied in the development of rapid nucleic acids detection systems. The Cas13 trans-cleavage activities are employed to successfully developed the "SHERLOCK" platform (for details, please refer to PMID: 28408723).
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