Doxorubicin Hydrochloride, USP

- Overview
  - Doxorubicin HCl is an anthracycline antibiotic and 12-hydroxylated version of daunorubicin that inhibits macromolecular biosynthesis through DNA intercalation.
    
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    Background
    
    Doxorubicin stops the development of the topoisomerase II enzyme, which relaxes supercoils in DNA for transcription. Doxorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, which prevents the DNA double helix from being resealed and thereby inhibits the replication process.
- Properties
  - CAS Number
    
    25316-40-9
    
    Molecular Formula
    
    C27H29NO11•HCl
    
    Molecular Weight
    
    579.98
    
    Appearance
    
    Orange-red crystalline powder
    
    Solubility
    
    Water: Soluble to 50 mM
    
    Other Properties
    
    Source: Streptomyces Peucetius
    Water Content (Karl Fischer): ≤4.0%
    PH: 4.0-5.5
    Assay: (On Dried Basis): 98.0-102.0%
    Melting Point: 204-205°C
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: Doxorubicin is given to treat non-Hodgkin's lymphoma, multiple myeloma, acute leukemias, Kaposi sarcoma, Ewing sarcoma, Wilm tumor, and cancers of the breast, adrenal cortex, endometrium, lung, ovary, and other sites. It is sometimes used to treat non-cancerous conditions as well.