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Overview
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Lasalocid Sodium is the salt form of Lasalocid, a carboxylic polyether ionophore. The compound has anticancer properties and antibacterial activity. Lasalocid is isolated from Streptomyces lasaliensis, first reported in 1951. It is also known as a coccidiostat; developed for the treatment of coccidia in animals, it stops coccidia from reproducing.
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Background
As an ionophore, the compound can increase the permeability of biological (or artificial) lipid membranes to specific ions. Lasalocid Sodium is an ionophore that can form complexes with cations and transport through lipid membranes. It can also transport larger organic cations.
In cancer studies, researchers found lasalocid induces autophagy through microtubule-associated protein 1 light chain 3 (LC-3)-II conversion. The autophagic properties were mediated by production of reactive oxygen species, confirmed by using a ROS inhibitor.
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- Properties
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Overview