Ketothiolide Diamine

Ketothiolide Diamine

Catalog Number:
BP01578682AME
Mfr. No.:
AM-BIOWAY0002
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    • Overview
      • Ketothiolide diamine (TK) is a small molecule compound with a dual-terminal primary amine structure. Its core is a reactive oxygen species (ROS)-responsive thioketal group, with amino groups at both ends. As a key "smart" crosslinking linker, it is structurally stable under normal physiological conditions, but its central chemical bond specifically breaks in the highly expressed ROS or reducing microenvironment of lesion tissue. This characteristic makes it widely used in constructing biodegradable biomaterials, such as as a chain extender introduced into the polyurethane backbone or in building drug delivery systems to achieve precise drug release at the lesion site.

        Product Features:
        • Ketothiolide small molecules can quickly penetrate the skin's base layer and effectively scavenge excess free radicals, providing deep antioxidant protection.
        • Through the strong reducing activity of the thiol group, it alleviates micro-inflammatory states, helps stabilize the cellular environment, and improves skin tolerance and overall stability.
        • It continuously neutralizes oxidative stress, slows down collagen and lipid damage, and delays skin aging from its source. 4. New raw materials with antioxidant and anti-inflammatory effects can be formed through chemical bonds and on other polymers.

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    • Properties
      • Categories
        Biomedical Polymers
    • Applications
      • Application Description
        This material is suitable for developing new raw materials with antioxidant and anti-inflammatory effects, slowing down collagen and lipid damage, delaying skin aging, and improving skin tolerance. Based on this material, a linear ROS-responsive, biodegradable unsaturated polyurethane was obtained, leading to the successful development of a multifunctional elastomer myocardial patch. This patch rapidly consumes ROS, reduces cardiomyocyte apoptosis, increases the M2/M1 macrophage phenotype ratio, and lowers the expression level of inflammatory factors. After implantation, it helps maintain similar cardiac function, ventricular size, wall thickness, and vascular maturity in infarcted hearts as in the sham-operated group.